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Recent Articles

Central Cementifying Fibroma of Mandible - A Case Report with Literature Review

Cementifying fibroma is a rare benign fibro-osseous tumor belonging to the same category as fibrous dysplasia and cemento-ossifyingdysplasia. Clinically it usually presents as a painless, slowly growing mass in the jaw and thus the lesion is frequently ignored by thepatient until the growth produces a noticeable swelling and facial deformity.

Access to and Utilisation of Adolescent Sexual and Reproductive Health Services among Secondary School Students in Mityana district, Uganda

The study of the access to and utilisation of Adolescent Sexual and Reproductive Health (ASRH) services among secondary school adolescents in, Mityana district was carried out in various schools in Ssekanyonyi sub-county. The study aimed to determine the prevalence of the ASRH burden, assess the utilisation of ASRH services in these schools and identify drivers/barriers to the utilisation of ASRH services among adolescents in secondary schools in Mityana district.

Preliminary Investigation of the Interaction of Misoprostol and Phenylbutazone on Bone Response to Injury in Horses

Phenylbutazone (PBZ) is commonly used in equine patients for treatment of orthopedic injuries. Phenylbutazone may adversely affect bone healing because of suppression of prostaglandin production. We hypothesized that administration of the prostaglandin analog misoprostol would enhance bone healing and mitigate the untoward effects of PBZ on bone response to injury in horses. The objectives of this study were to determine whether the administration of misoprostol would enhance bone healing and whether concurrent administration of PBZ and misoprostol would mitigate the untoward effects of phenylbutazone. Twenty horses were randomly assigned to one of four groups (n=5 per group): Group 1 (untreated control), Group 2 (phenylbutazone alone), Group 3 (misoprostol, alone), or Group 4 (concurrent treatment with phenylbutazone and misoprostol). A 4.5-mm diameter uni-cortical bone defect was created in one metacarpal III bone of all horses. Fluorochromic bone labels were administered intravenously on Days 0, 7, and 14. Computed tomographic osteoabsorptiometry and histomorphometric analyses were performed on the harvested metacarpal bones. Phenylbutazone treatment caused a decrease in endosteal new bone formation. Administration of misoprostol appeared to mitigate the magnitude of the PBZ effect on new bone formation (endosteal in-growth, p<0.06). Bone specific alkaline phosphatase serum activity decreased throughout the 14-day period of stall confinement. Mineral apposition rates increased in all groups during the period from 7 to 14 days after bone injury. Further research is needed to determine if this effect is significant. The administration of misoprostol may be beneficial to lessen the undesired impact of phenylbutazone on bone healing in horses.