Editorial Board Member - JPDD
Dr Santamaria Rita's research interests have concerned the following fields: tRNA metabolism; cloning and sequencing of cDNA for human aldolase B and protein C; chromosomal mapping of Becker muscular dystrophy gene, protein C and aldolase isoenzymes genes. Other contributions have concerned the study of hereditary diseases, as hemophilia A and B and hereditary fructose intolerance (HFI). In particular, for the HFI many novel mutations disease-related have been identified and the relationship genotype/phenotype was studied.
Current research field regards the molecular mechanisms regulating cellular iron homeostasis. In this context has been studied in different physio-pathological conditions, the expression and activity of main proteins involved in the metabolism of this metal, such as ferritin, transferrin receptor and Iron Regulatory Proteins (IRPs). In particular were studied: the effects of oxalomalic acid on IRPs activity and ferritin biosynthesis; the regulation of iron metabolism in neuronal cells exposed to hypoxia/reoxigenation; the effects of Bovine Herpes Virus 1 (BHV-1) infection on iron homeostasis in Madin-Darby bovine kidney (MDBK) cells; the iron metabolism in rat adipose tissue after ovariectomy and estrogen treatment; the iron metabolism in a bovine cell line exposed to dioxin; the iron metabolism during BHV-1 infection in the presence of TCDD in mammalian cells.
Topics of research collaboration have been: neuroprotective effects of cannabidiol; effects of oxalomalic acid on iNOS; cytotoxic/cytoprotective effects of natural origin substances; effects of protein chemotactic for monocytes-3 on smooth muscle cells human coronary artery; protein translation in rat skeletal muscle cells.
Other Editorial Board Members - JPDD
Department of Pharmacology and Pharmaceutical Sciences
University of Southern California
Faculty of Pharmaceutical Sciences
University of Kentucky
Department of Pharmaceutical Sciences
King Saud bin Abdulaziz University for Health Sciences
Division of Graduate Studies and Research
Institute of Technology Aguascalientes (ITA)
Technological Institute of Aguascalientes (ITA)
Department of Pharmacy
University of Bari Aldo Moro
Department of Pharmacy
University of Tromso
School of Health Sciences
Macao Polytechnic Institute
College of Pharmaceutical Sciences
Center for Drug Discovery